Montclaire
Aesthetics
Polynucleotide
Treatments in Barnes, London
Regenerative skin repair for stronger, calmer, better quality skin
Polynucleotides (PDRN) are a regenerative skin treatment designed to support the skin’s natural repair processes — improving overall skin quality, resilience and texture over time.
This is not a volumising filler treatment. It’s a skin-first approach for patients who want visible improvement that remains subtle, believable and well-kept.
What are Polynucleotides?
Polynucleotides are purified DNA fragments that support tissue repair and regeneration. In aesthetic medicine, they are used to improve skin quality by encouraging healthier skin function, hydration and elasticity.
This is not a filler and not a traditional skin booster. Polynucleotides are best understood as a regenerative skin treatment, focused on long-term skin health rather than instant change.
What Polynucleotides Can Improve
Polynucleotides are particularly effective for improving:
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Fine lines and crepey skin
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Skin texture and elasticity
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Dehydrated or stressed skin
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Fragile or thinning skin
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Reactive or rosacea-prone skin
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Post-inflammatory pigmentation
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Acne-prone skin and superficial scarring
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Delicate areas where traditional fillers are not appropriate
Areas Commonly Treated
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Face
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Under-eye area
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Neck
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Décolletage
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Hands
Your treatment plan is always tailored to your skin and the area being treated.
What Results Look Like (Realistic Expectations)
Polynucleotides do not create an instant or obvious result. Improvements develop gradually and are most often described as:
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Skin that appears calmer and more even
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Improved hydration and surface texture
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Softer fine lines
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Better skin elasticity and comfort
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A more rested, balanced appearance
The change is subtle — noticed more in the quality of the skin than in any visible alteration.
Who Polynucleotides Are Best Suited For
This treatment is particularly well suited if you:
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Prefer natural-looking results
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Want to improve skin quality rather than add volume
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Have skin that feels fragile, reactive or thin
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Are noticing early or progressive skin ageing
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Want to support long-term skin resilience
What to Expect From Your Appointment
Every appointment begins with a detailed assessment of your skin. The treatment is carefully planned and performed with precision, particularly when treating delicate areas.
You may experience:
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Mild redness
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Small bumps at injection sites
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Occasional bruising
These effects are usually temporary and settle within a short period.
Patient Experience
“So many compliments on my face. Thank you for the polynucleotides — I want more. The skin around my eyes has improved so much.”
Polynucleotides vs Other Skin Treatments
Polynucleotides differ from other injectable treatments:
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They do not add volume like dermal fillers
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They focus on skin repair, not reshaping
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They are particularly useful in delicate or fragile skin
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Results are gradual and regenerative, not immediate
They may be used alone or alongside treatments such as microneedling, skin boosters or collagen-stimulating injectables as part of a bespoke skin plan.
Book Polynucleotides in Barnes, London
If you would like to explore whether polynucleotides are right for your skin, a consultation will allow us to assess your skin properly and advise on the most appropriate treatment plan.
Frequently Asked Questions
What is the difference between polynucleotides and skin boosters?
Skin boosters primarily improve hydration. Polynucleotides focus on skin repair and regeneration, helping to improve skin quality, resilience and elasticity over time, particularly in fragile or thinning skin.
Are polynucleotides the same as dermal fillers?
No. Polynucleotides do not add volume or alter facial shape. They are a regenerative treatment designed to improve how the skin functions and behaves, rather than how it looks immediately.
How many treatments will I need?
Most patients benefit from a short course of treatments, usually spaced a few weeks apart. The exact number depends on your skin condition, the area treated and your long-term goals, which will be discussed during consultation.
When will I see results?
Results develop gradually. Many patients notice improvements in skin texture and comfort within a few weeks, with continued improvement as the skin regenerates over time.
Is there downtime?
Downtime is usually minimal. You may experience mild redness, small bumps or occasional bruising, particularly in delicate areas. These effects typically settle within 24–48 hours.
Can polynucleotides be used under the eyes?
Yes. Polynucleotides are often chosen for delicate areas such as the under-eye, where the aim is to improve skin quality and strength rather than add volume.
Can polynucleotides be combined with other treatments?
Yes. They are often combined with treatments such as microneedling, LED therapy, skin boosters or collagen-stimulating injectables as part of a bespoke skin plan.
Who is not suitable for polynucleotides?
Polynucleotides may not be suitable if you are pregnant or breastfeeding, have an active skin infection, or certain medical conditions. A full consultation is always carried out to assess suitability.
Why Choose Montclaire Aesthetics
At Montclaire, treatments are chosen for quality, safety and long-term outcomes, not trends.
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Medically led, experience-driven care
All treatments are performed by an experienced medical professional, with a strong focus on safety, anatomy and evidence-based practice. -
Bespoke treatment planning
No two faces or skins are treated the same. Every plan is tailored to skin quality, structure, lifestyle and long-term goals. -
Subtle, natural results
The emphasis is always on refinement rather than change. Treatments are designed to improve how the skin looks and behaves, without obvious intervention. -
Precision and restraint
Time is taken to treat carefully and conservatively, particularly in delicate areas, ensuring balanced and believable outcomes. -
A calm, private clinic environment
Montclaire offers discreet, one-to-one appointments in a relaxed setting, with continuity of care throughout your treatment journey.
Because ultimately,
the difference is simply in the quality of the skin.
Laura, July 2025
“Loving the effects of the polynucleotides, my skin has definitely improved"
Meg, August 2025
"I recently had a series of Polynucleotide treatment around my eyes, cannot tell you how thrilled I am with my results."
Sarah, Sept 2025
"So many compliments on my face, thank you for the polynucleotides, I want more. The skin around my eyes has improved so much"